Enantioselective Synthesis of 6,6-Disubstituted Pentafulvenes Containing a Chiral Pendant Hydroxy Group

Synthesis and Characterization of Polyamide Containing Maleimide Pendant Group

A series of new polyamides containing maleimide pendant group were prepared by low temperature polycondensation of 5-(4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)benzamido)isophthaloyl chloride as a new monomer with various aromatic diamines in NMP. Monomer and polymers structures were identified through FT-IR, 1H-NMR and elemental analysis. Obtained polymers were soluble in polar solvents and non solu...

synthesis and characterization of polyamide containing maleimide pendant group

Enantioselective synthesis of chiral heterocycles containing both chroman and pyrazolone derivatives catalysed by a chiral squaramide.

An efficient chiral squaramide-catalysed enantioselective Michael addition of pyrazolin-5-ones to 3-nitro-2H-chromenes for the synthesis of chiral heterocyclic systems containing both chroman and pyrazolone derivatives has been developed. This reaction afforded the desired products in high to excellent yields (up to 98%) with high enantioselectivities (up to 96%) and excellent diastereoselectiv...

Enantioselective Synthesis of Modafinil Drug using Chiral Complex of Titanium and Diethyltartarate

Modafinil (Diphenyl methyl Sulfinyl acetamid) is used clinically in the treatment of narcolepsy and sleeping disorders. The synthesis of R-modafinil, have started with the reaction of benzhydrol and thioglycolic acid in trifluoroacetic acid to afford benzhydryl sulfanyl acetic acid. The reaction of acid with thionyl chloride in benzene followed by treatment with ammonium hydroxide gave acetamid...

Chiral cobalt-catalyzed enantioselective aerobic oxidation of α-hydroxy esters.

A chiral cobalt-catalyzed enantioselective aerobic oxidative kinetic resolution of (±)-α-hydroxy esters, using molecular oxygen as a sole oxidant, is reported and a maximum of selectivity factor (s) 31.9 was achieved with >99% enantiomeric excess for unreacted α-hydroxy esters.